Evaluation of sperm proteins in infertile men: a proteomic approach.

نویسندگان

  • Stetson Thacker
  • Satya P Yadav
  • Rakesh K Sharma
  • Anthony Kashou
  • Belinda Willard
  • Dongmei Zhang
  • Ashok Agarwal
چکیده

In this study, the sperm protein profile was compared between fertile and infertile men using 2-dimensional gel electrophoresis, liquid chromatography mass spectrometer analysis, and matrix-assisted laser desorption ionization-time-of-flight-mass spectrometry. Four unique proteins, semenogelin II precursor, prolactin-induced protein, clusterin isoform 1, and prostate-specific antigen isoform 1 preproprotein, were predominantly present in the semen of healthy men; however, semenogelin II precursor and clusterin isoform 1 were not seen in the semen of infertile men, suggesting unique differences in the spermatozoa protein profiles of fertile and infertile men.

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عنوان ژورنال:
  • Fertility and sterility

دوره 95 8  شماره 

صفحات  -

تاریخ انتشار 2011